The 1846 Quarter Dollar has a middle-of-the-road mintage for a coin of this denomination from this decade. The mintage is almost half that of the 1843-O and the 1845, and is slightly higher than the 1841-O, the 1847-O and the 1849. However, original mintages have little to do with modern coin values, which are derived from the number of survivors, not from the number made. Thus, thanks to a decent mintage and a sufficient population of survivors, the 1846 remains one of the more affordable dates from the 1840's.
On the high end, PCGS has certtified only 17 Mint State 1846 Quarter Dollars, most of which grade MS63. The finest examples are a pair of PCGS MS65s. Because it was a product of the Philadelphia Mint, the 1846 Quarter Dollar usually features a strong strike and uniform detailiing.